LYMPHOID NEOPLASIA Brief report MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia
نویسندگان
چکیده
1Center of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; 2Center of Molecular Biology and Gene Therapy, Department of Internal Medicine–Hematooncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic; and 3Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
منابع مشابه
MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia.
MicroRNAs (miRNAs) play a key role in chronic lymphocytic leukemia as well as in normal B cells. Notably, miRNA gene encoding miR-650 and its homologs overlap with several variable (V) subgenes coding for lambda immunoglobulin (IgLλ). Recent studies describe the role of miR-650 in solid tumors, but its role in chronic lymphocytic leukemia (CLL) has not yet been studied. Our experiments demonstr...
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تاریخ انتشار 2012